A meta analysis of Ten randomized control trials on the role of neoadjuvant chemotherapy in early breast cancer was reported in Lancet Oncology by Early Breast Cancer Trialist Collaborative Group
It concludes ” Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered—eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy.”
Please find the link to the article here
Brahma’s life span is 100 years. Each year consists of 360 days. However, each day of Brahma’s life is equivalent to 432x 10 7 earth years. A similar number of years constitutes each night. At the end of one day all of creation has ended and next day creation happens all over again.
Each day is divided into 14 Manvantarams , each being under one Manu. Every Manvantaram is divided into 71 Maha Yugams. So, in effect, 14 Manvantarams have 14×71=994 Maha Yugams. Six Maha yugams is the period between two Manvantarams. This set of 1000 Mahayugams is called a Kalpam and that is a day in Brahma’s life.
Each Maha Yuga is composed of 4 Yugas.
Kruta Yuga-17,28,000 years
Treta Yuga-12,96,000 years
Dwapara Yuga-8,64,000 years
Kali Yuga-4,32,000 years
So-43,20,000 years is one Maha Yuga
तेषां ज्ञानी नित्ययुक्त एकभक्तिर्विशिष्यते |
प्रियो हि ज्ञानिनोsत्यर्थमहं स च मम प्रियः ||
Chapter 7 Verse 17
Of these, the wise man, ever steadfast and devoted to the One, excels; for , supremely dear am I to the wise and he is dear to me.
Interval cytoreduction with HIPEC (Hyperthermic Intraperitoneal chemotherapy) signficantly improves Recurrence free survival and overall survival when compared to surgery without HIPEC in stage 3 epithelial ovarian cancer
You can find the abstract here
Results of DESKTOP III ( Progression Free Survival) have been published recently in ASCO Abstracts
The median Progression free survival in patients undergoing secondary cytoreduction for relapsed ovarian cancer (with 6 months plus platinum free interval, positive AGO score ie., ECOG 0,<500 mL Ascites, complete resection at first surgery) was 19.6 months versus 14 months without surgery.
The abstract can be accessed here
यो न ह्रुष्यति न द्वेष्टि न शोचाति न काङ्क्षति |
शुभाशुभपरित्यागी भक्तिमान्यः स मे प्रियः ||
Chapter 12 Verse 17
He who neither rejoices nor hates nor grieves nor sesires, renouncing good and evil,full of devotion, he is dear to me.
कर्मण्यकर्म यः पश्येदकर्मणि च यः|
स बुद्धिमान्मनुष्येषु स युक्तः कृत्स्नकर्मक्र्त ||
He who sees inaction in action, and action in inaction, he is wise among men, he is a yogi and accomplisher of everything
Chapter 4 verse 18